L-Glutamic acid hydrochloride

Base Information

• Chemical Name: L-Glutamic acid hydrochloride
• CAS No.: 138-15-8
• Deprecated CAS: 125685-10-1
• Molecular Formula: C5H9NO4^.HCl
• Molecular Weight: 183.592
• Hs Code.: 29224200
• European Community (EC) Number: 205-315-9
• UNII: M0C2SP444T
• DSSTox Substance ID: DTXSID6047155
• Wikidata: Q27283300
• NCI Thesaurus Code: C28515
• ChEMBL ID: CHEMBL1255943
• Mol file: 138-15-8.mol

Synonyms:L-Glutamic acid hydrochloride;138-15-8;(S)-2-Aminopentanedioic acid hydrochloride;L-(+)-Glutamic acid hydrochloride;GLUTAMIC ACID HYDROCHLORIDE;Glutamic acid HCl;Acidogen;Acidulin;Gastuloric;Glutamidin;Hypochylin;L-Glutamic acid HCl;Acigluminum;Glutamidine;Acidalin;Acidoride;Acidothyn;Aciglumin;Antalka;Feracid;Flamithin;Flanithin;Glusatin;Glutasin;Hydrionic;Muriamic;Pepsdol;Aclor;Glutan hcl;Glutan-HCl;Glutan hydrochloride;L-Glutamic acid monohydrochloride;Glutamic acid, hydrochloride;UNII-M0C2SP444T;Clorhidrato de acido glutamico;Glutamic acid hydrogen chloride;M0C2SP444T;(2S)-2-aminopentanedioic acid;hydrochloride;DTXSID6047155;Glutamic acid, hydrochloride, L-;Glutamic acid, L-, hydrochloride;NSC 9239;NSC-9239;EINECS 205-315-9;L-Glutamic acid, hydrochloride [NF];alpha-Aminopentanedioic acid, hydrochloride, L-;L-Glutamic acid, hydrochloride;C5H9NO4.ClH;Hypochylin (TN);MFCD00012619;H-Glu-OH.HCl;H-Glu-OH HCL;MLS002153490;glutamic acid monohydrochloride;SCHEMBL176819;glutamic acid hydrochloride salt;CHEMBL1255943;DTXCID4027155;REGID_for_CID_2723891;RPAJSBKBKSSMLJ-DFWYDOINSA-N;AMY25301;DRG-0194;Tox21_302652;Tox21_500529;AKOS016003580;CCG-221833;CS-W017035;HY-W016319;L-Glutamic acid, hydrochloride (1:1);LP00529;GLUTAMIC ACID HYDROCHLORIDE [II];GLUTAMIC ACID HYDROCHLORIDE [MI];(S)-2-Aminopentanedioicacidhydrochloride;NCGC00093922-01;NCGC00256673-01;NCGC00261214-01;CAS-138-15-8;GLUTAMIC ACID HYDROCHLORIDE [HSDB];SMR001230835;GLUTAMIC ACID HYDROCHLORIDE [MART.];L-GLUTAMIC ACID HYDROCHLORIDE [FCC];EU-0100529;G0060;GLUTAMIC ACID HYDROCHLORIDE [WHO-DD];D07539;G 2128;L-GLUTAMIC ACID HYDROCHLORIDE [USP-RS];L-Glutamic acid hydrochloride, >=99% (HPLC);A807342;L-2-Aminoglutaric acid hydrochloride H-Glu-OH.HCl;Q-201298;Q27283300;S(+)-1-Aminopropane-1,3-dicarboxylic acid hydrochloride;L-Glutamic acid hydrochloride, United States Pharmacopeia (USP) Reference Standard

Chemical Property of L-Glutamic acid hydrochloride

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 2.55E-05mmHg at 25°C
• Melting Point: 214 °C (dec.)(lit.)
• Refractive Index: 24 ° (C=6, H2O)
• Boiling Point: 333.8 °C at 760 mmHg
• Flash Point: 155.7 °C
• PSA: 100.62000
• Density: 1.525
• LogP: 0.76540
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility.: 490 g/L (20 ºC)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 183.0298355
• Heavy Atom Count: 11
• Complexity: 145

Purity/Quality:

98.0% min ^*data from raw suppliers

L-Glutamic acid hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CC(=O)O)C(C(=O)O)N.Cl
• Isomeric SMILES: C(CC(=O)O)[C@@H](C(=O)O)N.Cl
• Recent ClinicalTrials: A Randomized Comparative Pharmacokinetic Study of Oral Ganciclovir After Treatment With Intravenous Ganciclovir for Cytomegalovirus Gastrointestinal Disease in AIDS Patients
• Uses: Glutamic Acid Hydrochloride is a flavoring, salt substitute that is soluble in water and very slightly soluble in alcohol and ether. It is obtained by chemical synthesis. L-Glutamic acid hydrochloride is used as a digestive aid. It is used in cell culture as a component of MEM non-essential amino acids solution. It has been used as a nitrogen source in the culture of Aspergillus fumigatus NRRL 2436 for fumagillin production.

Technology Process of L-Glutamic acid hydrochloride

There total 25 articles about L-Glutamic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Dicyclohexylammonium-<(S)-4-ethoxycarbonyl-4-(trifluoracetylamino)butanoat> (2709-66-2) → l-glutamic acid hydrochloride (138-15-8)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating;

Reference yield:

micropeptin MZ771 (1207348-80-8) → l-glutamic acid hydrochloride (138-15-8) + L-arginine hydrochloride (1119-34-2) + N-methyl-L-phenylalanine hydrochloride (66866-67-9,1956434-77-7) + L-isoleucine hydrochloride (17694-98-3) + L-threonine methyl ester hydrochloride (60143-52-4,71264-40-9,82650-07-5,97347-46-1,100157-61-7)

Guidance literature:

micropeptin MZ₇₇₁; With Jones reagent; In acetone; at 0 ℃; for 0.166667h;

With hydrogenchloride; water; at 110 ℃; for 16h; Sealed glass bomb;

DOI:10.1021/np900546u

Reference yield:

micropeptin MZ845 (914606-75-0) → D-glyceric acid (473-81-4,600-19-1,6000-40-4,28305-26-2,118916-26-0) + l-glutamic acid hydrochloride (138-15-8) + L-arginine hydrochloride (1119-34-2) + N-methyl-L-phenylalanine hydrochloride (66866-67-9,1956434-77-7) + L-isoleucine hydrochloride (17694-98-3) + L-threonine methyl ester hydrochloride (60143-52-4,71264-40-9,82650-07-5,97347-46-1,100157-61-7)

Guidance literature:

micropeptin MZ₈₄₅; With Jones reagent; In acetone; at 0 ℃; for 0.166667h;

With hydrogenchloride; water; at 110 ℃; for 16h; Sealed glass bomb;

DOI:10.1021/np900546u

upstream raw materials:

DL-threonine

Dicyclohexylammonium-<(S)-4-ethoxycarbonyl-4-(trifluoracetylamino)butanoat>

DL-glutamic acid hydrochloride

(2S)–N-acetyl-5-oxoproline methyl ester

Downstream raw materials:

L-glutamic acid di-tert-butyl ester hydrochloride

L-glutamic acid 5-methyl ester

N-tert-butoxycarbonyl glutamic acid tert-butyl ester

(2S)-2-[(tert-butoxy)carbonylamino]-4-(methoxycarbonyl)butanoic acid

Refernces

• 1、 Maleev, Victor I.,North, Michael,Larionov, Vladimir A.,Fedyanin, Ivan V.,Savel'Yeva, Tatyana F.,Moscalenko, Margarita A.,Smolyakov, Alexander F.,Belokon, Yuri N.. "Chiral octahedral complexes of cobalt(III) as "organic catalysts in disguise" for the asymmetric addition of a glycine schiff base ester to activated olefins". supporting information. p. 1803 - 1810. Retrieved 2014/06/09.
• 2、 -. "Resolution of DL-racemic mixtures". Page column 7-8. . Retrieved 2008/06/13.