4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one

Base Information

• Chemical Name: 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one
• CAS No.: 183500-17-6
• Molecular Formula: C₂₁H₃₂N₂O₃
• Molecular Weight: 360.497

Synonyms:4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one

Chemical Property of 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one

There total 8 articles about 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

((S)-1-{[(2-Chloro-acetyl)-(2,3-dimethyl-phenyl)-amino]-methyl}-pentyl)-carbamic acid tert-butyl ester (247593-34-6) → 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one (183500-17-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/jm990254z

Reference yield:

N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino)-hexanamine + chloroacetyl chloride (79-04-9) → 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one (183500-17-6)

Guidance literature:

With sodium hydrogencarbonate; In hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

chloroacetyl chloride (79-04-9) + N-(2,3-Dimethylphenyl)-2(S)-(tert-butoxycarbonylamino) hexanamine (186203-16-7) → 4-tert-Butoxycarbonyl-5(S)-n-butyl-1-(2,3-dimethylphenyl)piperazin-2-one (183500-17-6)

Guidance literature:

With sodium hydrogencarbonate; In hexane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

((S)-1-{[(2-Chloro-acetyl)-(2,3-dimethyl-phenyl)-amino]-methyl}-pentyl)-carbamic acid tert-butyl ester

(S)-N-Boc-leucinal

Boc-Nle-OH

N-Methoxy-N-methyl 2(S)-(tert-butoxycarbonylamino) hexanamide

Downstream raw materials:

5(S)-n-Butyl-1-(2,3-dimethylphenyl)-2-piperazinone

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