10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one

Base Information

• Chemical Name: 10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one
• CAS No.: 1429638-53-8
• Molecular Formula: C₂₇H₃₂O₄Si
• Molecular Weight: 448.634
• Mol file: 1429638-53-8.mol

Synonyms:10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one

Chemical Property of 10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one

There total 2 articles about 10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

Benzyloxymethyl chloride (3587-60-8) + 1-O-(tert-butyldiphenylsilyl)-1,3-dihydroxy-2-propanone (172843-09-3) → 10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one (1429638-53-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ol4005799

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one (1429638-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ol4005799

Reference yield: 88.0%

10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one (1429638-53-8) + isopropenylmagnesium bromide (13291-18-4) → 10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecan-6-ol (1429638-54-9)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/ol4005799

upstream raw materials:

Benzyloxymethyl chloride

1-O-(tert-butyldiphenylsilyl)-1,3-dihydroxy-2-propanone

tert-butylchlorodiphenylsilane

Downstream raw materials:

6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane

4-(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)butan-2-one

10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecan-6-ol