6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane

Base Information

• Chemical Name: 6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane
• CAS No.: 1429638-55-0
• Molecular Formula: C₃₆H₅₂O₄Si₂
• Molecular Weight: 604.977
• Mol file: 1429638-55-0.mol

Synonyms:6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane

Chemical Property of 6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane

There total 4 articles about 6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecan-6-ol (1429638-54-9) + t-butyldimethylsiyl triflate (69739-34-0) → 6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane (1429638-55-0)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol4005799

Reference yield:

1-O-(tert-butyldiphenylsilyl)-1,3-dihydroxy-2-propanone (172843-09-3) → 6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane (1429638-55-0)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol4005799

Reference yield:

10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one (1429638-53-8) → 6-(tert-butyldimethylsilyloxy)-10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecane (1429638-55-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With pyridine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ol4005799

upstream raw materials:

1-O-(tert-butyldiphenylsilyl)-1,3-dihydroxy-2-propanone

10,10-dimethyl-1,9,9-triphenyl-2,4,8-trioxa-9-silaundecan-6-one

10,10-dimethyl-1,9,9-triphenyl-6-(prop-1-en-2-yl)-2,4,8-trioxa-9-silaundecan-6-ol

t-butyldimethylsiyl triflate

Downstream raw materials:

4-(benzyloxymethoxy)-3-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)butan-2-one