Technology Process of C24H19F4N7O5S
There total 13 articles about C24H19F4N7O5S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-[(S)-2-amino-2-(3-fluoro-4-trifluoromethyl-phenyl)-ethyl]-N-methyl-4-nitro-benzenesulfonamide hydrochloride; 4-hydroxy-pyrido[3,2-d]pyrimidine-8-carboxamide;
With
N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
With
benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate;
In
dimethyl sulfoxide;
at 40 ℃;
for 12h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen; palladium 10% on activated carbon / 4 h / 20 °C
2.1: 96 h / 140 °C
3.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere
3.2: 12 h / 40 °C
With
palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine;
In
dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 12 h / 20 °C / Reflux
2.1: N,N-dimethyl-formamide / 13 h / 100 °C
3.1: sulfuric acid / water / 3 h / 70 °C
4.1: hydrogenchloride; ammonium chloride; iron / water; isopropyl alcohol / Reflux
5.1: 24 h / Reflux
6.1: sulfuric acid; potassium dichromate; Pyrimidin-2(1H)-one / water / 20 - 30 °C
7.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 70 °C
7.2: 70 °C
8.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.08 h / 20 °C / Inert atmosphere
8.2: 12 h / 40 °C
With
Pyrimidin-2(1H)-one; hydrogenchloride; potassium dichromate; sulfuric acid; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; phosphorus(V) oxybromide;
In
water; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;