(S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate

Base Information

Chemical Name:(S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate
CAS No.:331714-15-9
Molecular Formula:C₂₁H₃₁N₃O₆
Molecular Weight:421.494
Hs Code.:

Synonyms:(S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate

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Chemical Property of (S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate

Chemical Property:

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Technology Process of (S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate

There total 4 articles about (S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4530-20-5
BOC-glycine

: 14280-01-4
(2S)-N^α-benzoyllysine methyl ester hydrochloride

: 331714-15-9
(S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1021/ja003579+

Reference yield:

: 98-88-4
benzoyl chloride

: 331714-15-9
(S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / i-Pr₂NEt / CH₂Cl₂ / 1 h / 25 °C

2: aq. HCl / dioxane; CH₂Cl₂ / 3 h / 25 °C

3: PyBrOP; i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja003579+

Reference yield:

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 331714-15-9
(S)-methyl 2-(benzoylamino)-6-[2-(((tert-butyloxy)carbonyl)amino)-acetamido]hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / i-Pr₂NEt / CH₂Cl₂ / 1 h / 25 °C

2: aq. HCl / dioxane; CH₂Cl₂ / 3 h / 25 °C

3: PyBrOP; i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja003579+