3-ethynylphenylpropynal

Base Information

• Chemical Name: 3-ethynylphenylpropynal
• CAS No.: 315716-88-2
• Molecular Formula: C₁₁H₆O
• Molecular Weight: 154.168
• Mol file: 315716-88-2.mol

Synonyms:3-ethynylphenylpropynal

Chemical Property of 3-ethynylphenylpropynal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethynylphenylpropynal

There total 1 articles about 3-ethynylphenylpropynal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1,3-diethynylbenzene (1785-61-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-ethynylphenylpropynal (315716-88-2) + [3-(3-oxo-prop-1-ynyl)-phenyl]-propynal

Guidance literature:

1,3-diethynylbenzene; With ethylmagnesium bromide; In tetrahydrofuran; at -40 - 20 ℃;

N,N-dimethyl-formamide; at -20 - 20 ℃; for 18h; Further stages.;

DOI:10.1021/ol006570l

Reference yield: 93.0%

ethylene glycol (107-21-1) + 3-ethynylphenylpropynal (315716-88-2) → 3-ethynylphenylpropynal ethylene glycol acetal (315716-89-3)

Guidance literature:

With magnesium sulfate; toluene-4-sulfonic acid; In benzene; for 1h; Heating;

DOI:10.1021/ol006570l

Reference yield:

3-ethynylphenylpropynal (315716-88-2) → 1,6-bis[3-(3-oxopropynyl)phenyl]hexa-3-ene-1,5-diyne (315716-91-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / PTSA; MgSO₄ / benzene / 1 h / Heating

2: 67 percent / CuI; n-BuNH₂ / Pd(PPh₃)4 / benzene / 12 h / 20 °C

3: 32 percent / FeCl₃*6H₂O / CH₂Cl₂; acetone / 3 h / 20 °C

With copper(l) iodide; iron(III) chloride; magnesium sulfate; toluene-4-sulfonic acid; N-butylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; acetone; benzene; 1: Addition / 2: Condensation / 3: Hydrolysis;

DOI:10.1021/ol006570l

upstream raw materials:

1,3-diethynylbenzene

N,N-dimethyl-formamide

Downstream raw materials:

3-ethynylphenylpropynal ethylene glycol acetal

1,6-bis[3-(3-oxopropynyl)phenyl]hexa-3-ene-1,5-diyne

C₂₈H₂₀O₄