3-ethynylphenylpropynal ethylene glycol acetal

Base Information

• Chemical Name: 3-ethynylphenylpropynal ethylene glycol acetal
• CAS No.: 315716-89-3
• Molecular Formula: C₁₃H₁₀O₂
• Molecular Weight: 198.221
• Mol file: 315716-89-3.mol

Synonyms:3-ethynylphenylpropynal ethylene glycol acetal

Chemical Property of 3-ethynylphenylpropynal ethylene glycol acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-ethynylphenylpropynal ethylene glycol acetal

There total 2 articles about 3-ethynylphenylpropynal ethylene glycol acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethylene glycol (107-21-1) + 3-ethynylphenylpropynal (315716-88-2) → 3-ethynylphenylpropynal ethylene glycol acetal (315716-89-3)

Guidance literature:

With magnesium sulfate; toluene-4-sulfonic acid; In benzene; for 1h; Heating;

DOI:10.1021/ol006570l

Reference yield:

1,3-diethynylbenzene (1785-61-1) → 3-ethynylphenylpropynal ethylene glycol acetal (315716-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: EtMgBr / tetrahydrofuran / -40 - 20 °C

1.2: 52 percent / 18 h / -20 - 20 °C

2.1: 93 percent / PTSA; MgSO₄ / benzene / 1 h / Heating

With ethylmagnesium bromide; magnesium sulfate; toluene-4-sulfonic acid; In tetrahydrofuran; benzene; 1.1: Addition / 1.2: Formylation / 2.1: Addition;

DOI:10.1021/ol006570l

Reference yield: 67.0%

cis-1,2-Dichloroethylene (156-59-2,43695-79-0) + 3-ethynylphenylpropynal ethylene glycol acetal (315716-89-3) → C28H20O4 (315716-90-6)

Guidance literature:

With copper(l) iodide; N-butylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In benzene; at 20 ℃; for 12h;

DOI:10.1021/ol006570l

upstream raw materials:

ethylene glycol

3-ethynylphenylpropynal

1,3-diethynylbenzene

Downstream raw materials:

C₂₈H₂₀O₄

1,6-bis[3-(3-oxopropynyl)phenyl]hexa-3-ene-1,5-diyne