benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

Base Information

Chemical Name:benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate
CAS No.:1051442-86-4
Molecular Formula:C₂₂H₂₆F₃NO₃Si
Molecular Weight:437.534
Hs Code.:

Synonyms:benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

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Chemical Property of benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

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Technology Process of benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

There total 3 articles about benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 143505-42-4
1-[(4-methylphenyl)sulfinyl]-2-(trimethylsilyl)ethane

: 144008-26-4
3,3,3-Trifluoro-2-[(E)-4-methoxy-phenylimino]-propionic acid benzyl ester

: 1051442-86-4
benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

Guidance literature:: 1-[(4-methylphenyl)sulfinyl]-2-(trimethylsilyl)ethane; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -10 ℃; for 0.333333h;

3,3,3-Trifluoro-2-[(E)-4-methoxy-phenylimino]-propionic acid benzyl ester; In tetrahydrofuran; hexane; at -50 - -30 ℃; for 3h; Further stages.;
DOI:10.1016/j.jfluchem.2007.05.006

Reference yield:

: 75999-66-5
(Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)acetimidoyl chloride

: 1051442-86-4
benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium iodide / acetone

2.1: K₂CO₃ / Pd₂(dba)3 / toluene; dimethylformamide

3.1: lithium bis(trimethylsilyl)amide / hexane; tetrahydrofuran / 0.33 h / -10 °C

3.2: 32 percent / tetrahydrofuran; hexane / 3 h / -50 - -30 °C

With potassium carbonate; sodium iodide; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.jfluchem.2007.05.006

Reference yield:

: 134481-27-9
N-(p-Anisyl)-2,2,2-trifluoroacetimidoyl iodide

: 1051442-86-4
benzyl 2-[(4-methoxyphenyl)(trimethylsilyl)amino]-2-(trifluoromethyl)-3-butenoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: K₂CO₃ / Pd₂(dba)3 / toluene; dimethylformamide

2.1: lithium bis(trimethylsilyl)amide / hexane; tetrahydrofuran / 0.33 h / -10 °C

2.2: 32 percent / tetrahydrofuran; hexane / 3 h / -50 - -30 °C

With potassium carbonate; lithium hexamethyldisilazane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.jfluchem.2007.05.006