2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole

Base Information

• Chemical Name: 2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole
• CAS No.: 852172-24-8
• Molecular Formula: C₁₄H₁₂BFO₂
• Molecular Weight: 242.057

Synonyms:2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole

Chemical Property of 2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole

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Technology Process of 2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole

There total 3 articles about 2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

para-fluorostyrene (405-99-2) + benzo[1,3,2]dioxaborole (274-07-7) → 2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole (852172-24-8)

Guidance literature:

With potassium tert-butylate; In toluene; at 60 ℃; for 15h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.202000289

Reference yield:

para-fluorostyrene (405-99-2) + benzo[1,3,2]dioxaborole (274-07-7) → 4-FC6H4CH(Bcat)Me + 4-FC6H4CH2CH(Bcat)2 + 4-FC6H4CH=CH(Bcat) (1065498-68-1) + 2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole (852172-24-8)

Guidance literature:

Rh(acetylacetonato)(κ2-4-methoxy-N-((pyridin-2-yl)methylene)benzenamine); In benzene-d6; byproducts: FC6H4C2H5; B compd. in C6D6 added to a soln. of Rh complex and CH3OC6H4CHCH2, reacted at room temp. for 18 h; not isolated, detected by NMR, MS;

DOI:10.1021/ic800703n

Reference yield:

para-fluorostyrene (405-99-2) + 2,2'-bis(1,3,2-benzodioxaborole) (13826-27-2) → 2-[(S)-1-(4-Fluoro-phenyl)-ethyl]-benzo[1,3,2]dioxaborole + C20H15B2FO4 + C20H15B2FO4 + 2-[2-(4-fluorophenyl)ethyl]-benzo-1,3,2-dioxaborole (852172-24-8)

Guidance literature:

With [Rh(nbd)acac]; (S)-1-(2-(diphenylphosphanyl)naphthalen-1-yl)isoquinoline; In tetrahydrofuran; at 25 ℃; for 15h; Further byproducts given;

DOI:10.1016/j.tetasy.2005.02.016

upstream raw materials:

para-fluorostyrene

benzo[1,3,2]dioxaborole

2,2'-bis(1,3,2-benzodioxaborole)

Downstream raw materials:

(1S,2S,6R,8S)-4-[2-(4-Fluoro-phenyl)-ethyl]-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]decane

(1S,2S,6R,8S)-4-[(S)-1-Chloro-3-(4-fluoro-phenyl)-propyl]-2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.0^2,6]decane

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