(+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine

Base Information

Chemical Name:(+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine
CAS No.:100995-02-6
Molecular Formula:C₂₃H₂₄FN₅O₃
Molecular Weight:437.474
Hs Code.:

Synonyms:(+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine

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Chemical Property of (+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine

Chemical Property:

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Technology Process of (+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine

There total 4 articles about (+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85608-73-7
1,3-bis(benzyloxy)propan-2-yl 4-methylbenzene-1-sulfonate

: 100995-02-6
(+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine

Guidance literature:: Multi-step reaction with 4 steps

1: 15 percent / tetrabutylammonium fluoride / tetrahydrofuran; acetonitrile / 72 h / Heating

2: 54 percent / H₂ / palladium hydroxide on carbon / ethanol / 0.75 h / 2280 Torr

3: 87 percent / HCl / CH₂Cl₂ / 3 h / 0 °C

4: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, overnight

With hydrogenchloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; palladium dihydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm00155a039

Reference yield:

: 100994-99-8
1,3-bis(benzyloxy)-2-fluoropropane

: 100995-02-6
(+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / H₂ / palladium hydroxide on carbon / ethanol / 0.75 h / 2280 Torr

2: 87 percent / HCl / CH₂Cl₂ / 3 h / 0 °C

3: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, overnight

With hydrogenchloride; hydrogen; sodium hydride; palladium dihydroxide; In ethanol; dichloromethane;
DOI:10.1021/jm00155a039

Reference yield:

: 112482-37-8
(+/-)-3-(benzyloxy)-2-fluoro-1-propanol

: 100995-02-6
(+/-)-2-amino-6-(benzyloxy)-9-<<3-(benzyloxy)-2-fluoro-1-propoxy>methyl>purine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / HCl / CH₂Cl₂ / 3 h / 0 °C

2: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, overnight

With hydrogenchloride; sodium hydride; In dichloromethane;
DOI:10.1021/jm00155a039