bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate

Base Information

Chemical Name:bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate
CAS No.:168204-21-5
Molecular Formula:C₆₂H₆₀N₃O₆PSi₂
Molecular Weight:1030.32
Hs Code.:

Synonyms:bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate

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Chemical Property of bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate

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Technology Process of bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate

There total 9 articles about bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.1%

: 168204-19-1
(8-hydroxy-2-quinolyl)methylphosphonic acid

: 168204-20-4
O-(tert-butyldiphenylsilyloxy-2-quinolyl)methyl-N,N'-dicyclohexylisourea

: 168204-21-5
bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate

Guidance literature:: In N,N-dimethyl-formamide; benzene; at 80 ℃; for 42h;
DOI:10.1021/ja00133a013

Reference yield:

: 826-81-3
2-methyl-8-quinolinol

: 168204-21-5
bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate

Guidance literature:: Multi-step reaction with 5 steps

1: 84.1 percent / imidazole / dimethylformamide / 72 h / Ambient temperature

2: 76.7 percent / SeO₂ / dioxane / 24 h / 75 °C

3: 93.8 percent / NaBH₄ / ethanol / 6 h / Ambient temperature

4: 88.4 percent / CuCl / 1.) 50 deg C, 1 h, 2.) RT, 24 h

5: 51.1 percent / dimethylformamide; benzene / 42 h / 80 °C

With 1H-imidazole; sodium tetrahydroborate; selenium(IV) oxide; copper(l) chloride; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00133a013

Reference yield:

: 155933-77-0
<8-<(tert-butyldiphenylsilyl)oxy>quinolyl>methanol

: 168204-21-5
bis<(8-tert-butyldiphenylsilyloxy-2-quinolyl)methyl> (8-hydroxy-2-quinolyl)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 88.4 percent / CuCl / 1.) 50 deg C, 1 h, 2.) RT, 24 h

2: 51.1 percent / dimethylformamide; benzene / 42 h / 80 °C

With copper(l) chloride; In N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00133a013