2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

Base Information

Chemical Name:2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine
CAS No.:1536391-31-7
Molecular Formula:C₂₁H₁₇ClF₂N₄O
Molecular Weight:414.842
Hs Code.:

Synonyms:2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

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Chemical Property of 2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

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Technology Process of 2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

There total 1 articles about 2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1536391-31-7
2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 16 h / 80 °C

2: toluene / 1.67 h / 100 °C

3: sodium tetrahydroborate; methanol / 1.25 h / 0 °C

4: triethylsilane; boron trifluoride diethyl etherate / 20 h / 20 °C / Inert atmosphere

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; tri-tert-butyl phosphine / 1,4-dioxane; water / 1 h / 110 - 120 °C / Inert atmosphere

With methanol; triethylsilane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tri-tert-butyl phosphine; boron trifluoride diethyl etherate; sodium carbonate; In 1,4-dioxane; methanol; water; toluene;

Reference yield: 26.0%

: 1536391-31-7
2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

: 72580-53-1
(S)-(+)-3-pyrrolidinecarboxylic acid

: 1536380-87-6
(3S)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]pyrrolidine-3-carboxylic acid

Guidance literature:: With triethylamine; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 1h; Microwave irradiation;

Reference yield: 22.0%

: 1536391-31-7
2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

: 498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(R)-nipecotic acid

: 1536381-11-9
ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate

Guidance literature:: 2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine; (R)-nipecotic acid; With triethylamine; In 1,4-dioxane; at 100 ℃; for 1h; Microwave irradiation;

With ammonium hydroxide; In acetonitrile;