ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate

Base Information

Chemical Name:ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate
CAS No.:1536381-11-9
Molecular Formula:C₂₇H₂₇F₂N₅O₃*H₃N
Molecular Weight:524.57
Hs Code.:

Synonyms:ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate

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Chemical Property of ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate

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Technology Process of ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate

There total 2 articles about ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1536391-31-7
2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine

: 498-95-3,25137-00-2,59045-82-8,60252-41-7,262853-93-0
(R)-nipecotic acid

: 1536381-11-9
ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate

Guidance literature:: 2-chloro-5-{3-[2-(difluoromethoxy)benzyl]-2,7-dimethylimidazo[1,2-a]pyridin-6-yl}-pyrimidine; (R)-nipecotic acid; With triethylamine; In 1,4-dioxane; at 100 ℃; for 1h; Microwave irradiation;

With ammonium hydroxide; In acetonitrile;

Reference yield:

: 98198-48-2
2-amino-5-bromo-4-methylpyridine

: 1536381-11-9
ammonium (3R)-1-[5-(3-{[2-(difluoromethoxy)phenyl]methyl}-2,7-dimethylimidazo[1,2-a]pyridin-6-yl)pyrimidin-2-yl]piperidine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol / 16 h / 80 °C

2.1: toluene / 1.67 h / 100 °C

3.1: sodium tetrahydroborate; methanol / 1.25 h / 0 °C

4.1: triethylsilane; boron trifluoride diethyl etherate / 20 h / 20 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; tri-tert-butyl phosphine / 1,4-dioxane; water / 1 h / 110 - 120 °C / Inert atmosphere

6.1: triethylamine / 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

6.2: C₁₈ column

With methanol; triethylsilane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tri-tert-butyl phosphine; boron trifluoride diethyl etherate; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; water; toluene;