2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

Base Information

• Chemical Name: 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide
• CAS No.: 723278-29-3
• Molecular Formula: C₂₃H₂₁ClFN₅O₃S
• Molecular Weight: 501.969

Synonyms:2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

Chemical Property of 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

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Technology Process of 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

There total 13 articles about 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(2-amino-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide (385785-31-9) + E-N'-(5-(3-chloropropoxy)-2-cyano-4-methoxyphenyl)-N,N-dimethylformimidamide → 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide (723278-29-3)

Guidance literature:

With acetic acid; at 135 ℃; for 3h;

DOI:10.1021/jm050786h

Reference yield: 77.0%

→ 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide (723278-29-3)

Guidance literature:

Reference yield: 73.0%

N’-(2-cyano-5-(3-chloropropoxy)-4-methoxyphenyl)-N,N-dimethylformamidine (385785-04-6) + tert-butyl 5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1,3-thiazol-2-ylcarbamate (723278-26-0) → 2-(2-{[7-(3-chloropropoxy)-6-methoxyquinazolin-4-yl]amino}-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide (723278-29-3)

Guidance literature:

In acetic acid; for 2h; Heating / reflux;

upstream raw materials:

2-(2-amino-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

2-amino-4-(benzyloxy)-5-methoxybenzonitrile

4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile

[2-(tritylamino)-1,3-thiazol-5-yl]acetic acid

Downstream raw materials:

2-(2-((7-(3-((2S)-2-((ethyl-(2-hydroxyethyl)amino)methyl)pyrrolidin-1-yl)propoxy)-6-methoxyquinazolin-4-yl)amino)-1,3-thiazol-5-yl)-N-(3-fluorophenyl) acetamide

2-(2-((7-(3-((2-fluoroethyl)-(2-hydroxyethyl)amino)propoxy)-6-methoxyquinazolin-4-yl)amino)-1,3-thiazol-5-yl)-N-(3-fluorophenyl)acetamide

N-(3-fluorophenyl)-2-(2-((7-(3-((2-hydroxyethyl)-(2-methoxyethyl)amino)propoxy)-6-methoxyquinazolin-4-yl)-amino)-1,3-thiazol-5-yl)acetamide

di-tert-butyl {1-[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1,3-thiazol-2-yl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]piperidin-4-yl}methyl phosphate

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