3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole

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Chemical Name:3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole
CAS No.:1422985-29-2
Molecular Formula:C₁₈H₁₂F₆N₂O₂
Molecular Weight:402.296
Hs Code.:

Synonyms:3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole

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Chemical Property of 3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole

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Technology Process of 3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole

There total 3 articles about 3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 120-72-9
indole

: 1422985-10-1
(E)-1-(3,3,3-trifluoro-1-nitroprop-1-en-2-yl)-4-(trifluoromethyl)benzene

: 1422985-29-2
3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole

Guidance literature:: With nickel(II) perchlorate hexahydrate; 2,2-bis<2-<4(R),5(R)-diphenyl-1,3-oxazolinyl>>propane; In toluene; at 60 ℃; enantioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1021/ja400650m

Reference yield:

: 74853-66-0
4'-trifluoromethyl-2,2,2-trifluoroacetophenone

: 1422985-29-2
3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 20 °C

2: thionyl chloride; pyridine / toluene / 3 h / 0 - 20 °C

3: nickel(II) perchlorate hexahydrate; 2,2-bis<2-<4(R),5(R)-diphenyl-1,3-oxazolinyl>>propane / toluene / 60 °C / Schlenk technique; Inert atmosphere

With pyridine; thionyl chloride; nickel(II) perchlorate hexahydrate; triethylamine; 2,2-bis<2-<4(R),5(R)-diphenyl-1,3-oxazolinyl>>propane; In toluene; 1: |Henry Nitro Aldol Condensation / 3: |Friedel-Crafts Alkylation;
DOI:10.1021/ja400650m

Reference yield:

: 1422984-91-5
C₁₀H₇F₆NO₃

: 1422985-29-2
3-(1,1,1-trifluoro-3-nitro-2-(4-(trifluoromethyl)phenyl)propan-2-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; pyridine / toluene / 3 h / 0 - 20 °C

2: nickel(II) perchlorate hexahydrate; 2,2-bis<2-<4(R),5(R)-diphenyl-1,3-oxazolinyl>>propane / toluene / 60 °C / Schlenk technique; Inert atmosphere

With pyridine; thionyl chloride; nickel(II) perchlorate hexahydrate; 2,2-bis<2-<4(R),5(R)-diphenyl-1,3-oxazolinyl>>propane; In toluene; 2: |Friedel-Crafts Alkylation;
DOI:10.1021/ja400650m