2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

Base Information

Chemical Name:2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}
CAS No.:870196-25-1
Molecular Formula:C₄₁H₅₅N₃O₃SSi₂
Molecular Weight:726.143
Hs Code.:

2-amino-pentanedioic acid 5-amide 1-{[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-1-(<i>tert</i>-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

Synonyms:2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

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Chemical Property of 2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

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Technology Process of 2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

There total 9 articles about 2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 870196-24-0
{1-[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propylcarbamoyl]-3-carbamoyl-propyl}-carbamic acid tert-butyl ester

: 870196-25-1
2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 23 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2005.07.073

Reference yield:

: 870196-18-2
[2-(tert-butyl-diphenyl-silanyloxy)-1-hydroxymethyl-propyl]-carbamic acid tert-butyl ester

: 870196-25-1
2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / Et₃N; PPh₃; CBr₄ / CH₂Cl₂ / 18 h / 23 °C

2: 96 percent / tetrahydrofuran / 19 h / -78 - 23 °C

3: 82 percent / HCl / ethyl acetate / 0.33 h / 23 °C

4: 61 percent / PyBOP; DIEA / CH₂Cl₂ / 18 h / 23 °C

5: 73 percent / HCl / ethyl acetate / 0.5 h / 23 °C

With hydrogenchloride; carbon tetrabromide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2005.07.073

Reference yield:

: 870196-19-3
[1-bromomethyl-2-(tert-butyl-diphenyl-silanyloxy)-propyl]-carbamic acid tert-butyl ester

: 870196-25-1
2-amino-pentanedioic acid 5-amide 1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(tert-butyl-diphenyl-silanylsulfanylmethyl)-propyl]-amide}

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / tetrahydrofuran / 19 h / -78 - 23 °C

2: 82 percent / HCl / ethyl acetate / 0.33 h / 23 °C

3: 61 percent / PyBOP; DIEA / CH₂Cl₂ / 18 h / 23 °C

4: 73 percent / HCl / ethyl acetate / 0.5 h / 23 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.bmcl.2005.07.073