(Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester

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Chemical Name:(Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester
CAS No.:132245-85-3
Molecular Formula:C₂₄H₄₅N₂O₆PSi₂
Molecular Weight:544.776
Hs Code.:

Synonyms:(Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester

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Chemical Property of (Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester

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Technology Process of (Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester

There total 10 articles about (Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 132245-84-2
({(E)-2-[3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-tert-butoxycarbonylamino-methyl)-phosphonic acid dimethyl ester

: 132245-85-3
(Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4039(00)97256-3

Reference yield:

: 99815-16-4
3,4-bis(tert-butyldimethylsilanyloxy)benzaldehyde

: 132245-85-3
(Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / ZnI₂

2: LiAlH₄ / tetrahydrofuran

3: CH₂Cl₂

4: 75 percent / n-Bu₃P / tetrahydrofuran

5: 100 percent / 30percent TFA / CH₂Cl₂

6: 85 percent / DCC / CH₂Cl₂

7: 78 percent / H₂O₂, pyridine / tetrahydrofuran

8: 100 percent / TFA / CH₂Cl₂

With pyridine; lithium aluminium tetrahydride; tributylphosphine; dihydrogen peroxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc(II) iodide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)97256-3

Reference yield:

: 132245-81-9
2-Amino-1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-ethanol

: 132245-85-3
(Amino-{(E)-2-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-phenyl]-vinylcarbamoyl}-methyl)-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: CH₂Cl₂

2: 75 percent / n-Bu₃P / tetrahydrofuran

3: 100 percent / 30percent TFA / CH₂Cl₂

4: 85 percent / DCC / CH₂Cl₂

5: 78 percent / H₂O₂, pyridine / tetrahydrofuran

6: 100 percent / TFA / CH₂Cl₂

With pyridine; tributylphosphine; dihydrogen peroxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4039(00)97256-3