(S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

Base Information

Chemical Name:(S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol
CAS No.:1632157-53-9
Molecular Formula:C₂₃H₃₆O₇
Molecular Weight:424.535
Hs Code.:

Synonyms:(S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

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Chemical Property of (S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

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Technology Process of (S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

There total 5 articles about (S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1632157-52-8
1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)propan-2-one

: 3-(2-methyl-1,3-dioxolan-2-yl)prop-1-yl magnesium bromide

: 1632157-54-0
(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

: 1632157-53-9
(S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

Guidance literature:: With magnesium bromide ethyl etherate; In dichloromethane; at -78 ℃; for 2h; stereoselective reaction;
DOI:10.1055/s-0033-1340163

Reference yield:

: 102389-96-8
(2R,3R)-3-hydroxy-1,2-O-isopropylidene-3-p-methoxyphenyl-1,2-propanediol

: 1632157-54-0
(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

: 1632157-53-9
(S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

2: ozone / methanol; dichloromethane / 2 h / -78 - 20 °C

3: magnesium bromide ethyl etherate / dichloromethane / 2 h / -78 °C

With sodium hydride; ozone; magnesium bromide ethyl etherate; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0033-1340163

Reference yield:

: 15186-48-8
2,3-isopropylidene-glyceraldehyde

: 1632157-54-0
(R)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

: 1632157-53-9
(S)-1-((R)-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)(4-methoxyphenyl)methoxy)-2-methyl-5-(2-methyl-1,3-dioxolan-2-yl)pentan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

1.3: pH 9 / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 °C

3.1: ozone / methanol; dichloromethane / 2 h / -78 - 20 °C

4.1: magnesium bromide ethyl etherate / dichloromethane / 2 h / -78 °C

With copper(l) iodide; sodium hydride; ozone; magnesium bromide ethyl etherate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1055/s-0033-1340163