(1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester

Base Information

• Chemical Name: (1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester
• CAS No.: 1201512-36-8
• Molecular Formula: C₂₄H₂₉NO₅
• Molecular Weight: 411.498

Synonyms:(1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester

Chemical Property of (1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester

There total 1 articles about (1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid (1201512-34-6) → (1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester (1201512-36-8)

Guidance literature:

With trimethylsilyldiazomethane; In diethyl ether; toluene; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.200900996

Reference yield: 95.0%

(1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester (1201512-36-8) → (1S,4S,5S,6R)-7-benzyl-5-benzyloxy-4-hydroxymethyl-3,3-dimethyl-2-oxa-7-azabicyclo[4.2.0]octan-8-one (1201512-44-8)

Guidance literature:

With samarium; 1,2-Diiodoethane; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/chem.200900996

Reference yield: 86.0%

di-tert-butyl dicarbonate (24424-99-5) + (1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid methyl ester (1201512-36-8) → (2S,3R,4S,5S)-4-benzyloxy-3-tert-butoxycarbonylamino-5-hydroxymethyl-6,6-dimethyltetrahydropyran-2-carboxylic acid methyl ester (1201512-42-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 72h;

DOI:10.1002/chem.200900996

upstream raw materials:

methanol

(1R,5S,8S,9S)-2-benzyl-9-benzyloxy-6,6-dimethyl-3,7-dioxa-2-azabicyclo[3.3.1]nonane-8-carboxylic acid

Downstream raw materials:

(1S,4S,5S,6R)-7-benzyl-5-benzyloxy-4-hydroxymethyl-3,3-dimethyl-2-oxa-7-azabicyclo[4.2.0]octan-8-one

(2S,3R,4S,5S)-4-benzyloxy-3-tert-butoxycarbonylamino-5-hydroxymethyl-6,6-dimethyltetrahydropyran-2-carboxylic acid methyl ester

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