(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

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Chemical Name:(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide
CAS No.:1068601-51-3
Molecular Formula:C₂₇H₃₁NO₂
Molecular Weight:401.549
Hs Code.:

Synonyms:(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

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Technology Process of (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

There total 2 articles about (R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 100-39-0
benzyl bromide

: 159345-11-6
(S)-N-((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-phenyl-butyramide

: 1068601-51-3
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

Guidance literature:: (S)-N-((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-phenyl-butyramide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

benzyl bromide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -40 ℃; for 1.25h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield: 91.0%

: 1068600-91-8
(2R)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

: 100-39-0
benzyl bromide

: 1068601-51-3
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

Guidance literature:: (2R)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

benzyl bromide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at -40 ℃; for 1.25h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja806021y

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 1068601-51-3
(R)-2-benzyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methyl-2-phenylbutanamide

: 925675-38-3
2-(1-benzyl-1-phenyl-propyl)-3,4-dimethyl-5-phenyl-4,5-dihydro-oxazol-3-ium; trifluoro-methanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 0.166667h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ja806021y