ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate

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Chemical Name:ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate
CAS No.:1428526-47-9
Molecular Formula:C₂₄H₂₂N₅O₅P
Molecular Weight:491.443
Hs Code.:

Synonyms:ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate

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Chemical Property of ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate

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Technology Process of ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate

There total 13 articles about ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1428526-46-8
diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

: 1428526-47-9
ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate

Guidance literature:: diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate; With sodium hydroxide; In 1,4-dioxane; Reflux;

With trifluoroacetic acid;

Reference yield:

: 6311-35-9
6-bromonicotinic acid

: 1428526-47-9
ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate

Guidance literature:: Multi-step reaction with 9 steps

1: thionyl chloride / 3 h / Reflux

2: aluminum (III) chloride / 6 h / Reflux

3: hydroxylamine hydrochloride; sodium carbonate / ethanol / 3 h / Reflux

4: sodium tetrahydroborate; titanium tetrachloride / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 0 - 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux; Inert atmosphere

7: hydrogenchloride / 1,4-dioxane / 20 °C

8: triethylamine; HATU / ethyl acetate / 2 h / 20 °C

9: sodium hydroxide / 1,4-dioxane / Reflux

With hydrogenchloride; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; titanium tetrachloride; sodium carbonate; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate;

Reference yield:

: 80100-16-9
(6-bromopyridin-3-yl)(phenyl)methanone

: 1428526-47-9
ethyl hydrogen (5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-yl)phosphonate

Guidance literature:: Multi-step reaction with 7 steps

1: hydroxylamine hydrochloride; sodium carbonate / ethanol / 3 h / Reflux

2: sodium tetrahydroborate; titanium tetrachloride / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0 - 20 °C

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux; Inert atmosphere

5: hydrogenchloride / 1,4-dioxane / 20 °C

6: triethylamine; HATU / ethyl acetate / 2 h / 20 °C

7: sodium hydroxide / 1,4-dioxane / Reflux

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; hydroxylamine hydrochloride; titanium tetrachloride; sodium carbonate; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate;