diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

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Chemical Name:diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate
CAS No.:1428526-46-8
Molecular Formula:C₂₆H₂₆N₅O₅P
Molecular Weight:519.497
Hs Code.:

Synonyms:diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

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Chemical Property of diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

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Technology Process of diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

There total 12 articles about diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1428526-45-7
diethyl {5-[amino(phenyl)methyl]pyridin-2-yl}phosphonate

: 56406-45-2
4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid

: 1428526-46-8
diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

Guidance literature:: With triethylamine; HATU; In ethyl acetate; at 20 ℃; for 2h;

Reference yield: 15.0%

: 1428618-76-1
diethyl {5-[amino(phenyl)methyl]pyridin-2-yl}phosphonate

: 56406-45-2
4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxylic acid

: 1428526-46-8
diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

Guidance literature:: With triethylamine; HATU; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

: 6311-35-9
6-bromonicotinic acid

: 1428526-46-8
diethyl 5-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)pyridin-2-ylphosphonate

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / 3 h / Reflux

2: aluminum (III) chloride / 6 h / Reflux

3: hydroxylamine hydrochloride; sodium carbonate / ethanol / 3 h / Reflux

4: sodium tetrahydroborate; titanium tetrachloride / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere

5: triethylamine / dichloromethane / 0 - 20 °C

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / tetrahydrofuran / Reflux; Inert atmosphere

7: hydrogenchloride / 1,4-dioxane / 20 °C

8: triethylamine; HATU / ethyl acetate / 2 h / 20 °C

With hydrogenchloride; aluminum (III) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; titanium tetrachloride; sodium carbonate; triethylamine; HATU; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; ethyl acetate;