(2-Amino-1-hydroxyethyl)phosphonic acid

Base Information

• Chemical Name: (2-Amino-1-hydroxyethyl)phosphonic acid
• CAS No.: 115511-00-7
• Molecular Formula: C₂H₈NO₄P
• Molecular Weight: 141.064
• Mol file: 115511-00-7.mol

Synonyms:(R)-(-)-(2-Amino-1-hydroxyethyl)phosphonsaeure

Chemical Property of (2-Amino-1-hydroxyethyl)phosphonic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

(2-AMINO-1-HYDROXYETHYL)PHOSPHONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-Amino-1-hydroxyethyl)phosphonic acid

There total 6 articles about (2-Amino-1-hydroxyethyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(+)-diethyl cyanohydroxymethylphosphonate → (R)-(-)-(2-Amino-1-hydroxyethyl)phosphonsaeure (115511-00-7)

Guidance literature:

(+)-diethyl cyanohydroxymethylphosphonate; With borane-THF; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In water; for 8h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201702904

Reference yield:

((R)-2-Benzylamino-1-hydroxy-ethyl)-phosphonic acid → (R)-(-)-(2-Amino-1-hydroxyethyl)phosphonsaeure (115511-00-7)

Guidance literature:

With hydrogen; acetic acid; palladium; In water; at 20 ℃; for 48h; under 760 Torr;

DOI:10.1016/S0040-4039(99)01259-9

Reference yield:

(R)-(-)-<2-Azido-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester (121330-02-7) → (R)-(-)-(2-Amino-1-hydroxyethyl)phosphonsaeure (115511-00-7)

Guidance literature:

With hydrogenchloride; palladium on activated charcoal; hydrogen; Yield given. Multistep reaction; 1.) EtOH, 3.7 bar H₂, 20 h, 2.) reflux, 20 h.;

upstream raw materials:

(R)-(+)-(2-Amino<1-D1>ethyl)phosphonsaeure

(R)-(-)-<2-Azido-1-(tert-butyldimethylsiloxy)ethyl>phosphonsaeure-dimethylester

(2-aminethyl)phosphonic acid

Downstream raw materials:

Benzoic acid (R)-2-benzoylamino-1-(dimethoxy-phosphoryl)-ethyl ester

phosphoric acid

glycine