(Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

Base Information

Chemical Name:(Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol
CAS No.:211758-84-8
Molecular Formula:C₃₀H₃₆N₂O₃S
Molecular Weight:504.693
Hs Code.:

Synonyms:(Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

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Chemical Property of (Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

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Technology Process of (Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

There total 10 articles about (Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 211758-83-7
(Z,Z)-3-[5-(tert-butyldimethylsiloxy)pent-3-en-1-yl]-2-(6-{[4-methoxy-2-(phenylsulfanyl)methyl]pyridyn-3-yl}hex-3-en-1-yl)-4-methoxypyridine

: 211758-84-8
(Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 17h; Ambient temperature;
DOI:10.1021/jo9801770

Reference yield:

: 5470-66-6
2-methyl-4-nitropyridine N-oxide

: 211758-84-8
(Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / PCl₃ / CHCl₃ / 40 h / Ambient temperature

2: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

3: 83 percent / methanol / Ambient temperature

4: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.83 h / Ambient temperature

5: 99 percent / Na/Hg, NaH₂PO₄ / methanol / 1 h

6: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 30 min

8: 94 percent / aq. HCl / tetrahydrofuran / 17 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium dihydrogenphosphate; sodium amalgam; n-butyllithium; phosphorus trichloride; In tetrahydrofuran; methanol; hexane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jo9801770

Reference yield:

: 13508-96-8
2-methyl-4-nitro-pyridine

: 211758-84-8
(Z)-5-{4-Methoxy-2-[(Z)-6-(4-methoxy-2-phenylsulfanylmethyl-pyridin-3-yl)-hex-3-enyl]-pyridin-3-yl}-pent-2-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 50 percent / NaOH / dimethylsulfoxide / 0.5 h / 15 - 20 °C

2: 83 percent / methanol / Ambient temperature

3: 86 percent / n-BuLi / tetrahydrofuran; hexane / 0.83 h / Ambient temperature

4: 99 percent / Na/Hg, NaH₂PO₄ / methanol / 1 h

5: 1.) n-BuLi / 1.) THF, -78 to -50 deg C, 40 min, 2.) THF, -50 deg C, 5 min, then room temp., 30 min

7: 94 percent / aq. HCl / tetrahydrofuran / 17 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium dihydrogenphosphate; sodium amalgam; n-butyllithium; In tetrahydrofuran; methanol; hexane; dimethyl sulfoxide;
DOI:10.1021/jo9801770