Technology Process of N-[3-(4-methylpiperidin-1-yl)propyl]-3-{2-[(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxamide
There total 11 articles about N-[3-(4-methylpiperidin-1-yl)propyl]-3-{2-[(methylsulfonyl)amino]phenyl}-11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-8-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine; HATU;
In
N,N-dimethyl acetamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; copper / chlorobenzene / 135 °C
2.1: hydrogenchloride / water; methanol / Reflux
3.1: cesium fluoride / DavePhos; palladium diacetate / N,N-dimethyl acetamide; methanol / 48 h / Inert atmosphere; Reflux
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
4.2: pH 2 - 3
5.1: triethylamine; HATU / N,N-dimethyl acetamide / 20 °C
With
hydrogenchloride; water; copper; potassium carbonate; triethylamine; cesium fluoride; HATU; sodium hydroxide;
palladium diacetate; DavePhos;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; chlorobenzene;
3.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate; copper / chlorobenzene / 18 h / Reflux
2.1: hydrogenchloride / water; methanol / 18 h / Reflux
3.1: cesium fluoride / DavePhos; palladium diacetate / N,N-dimethyl acetamide; methanol / 48 h / Inert atmosphere; Reflux
4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 20 °C
4.2: pH 2 - 3
5.1: triethylamine; HATU / N,N-dimethyl acetamide / 20 °C
With
hydrogenchloride; water; copper; potassium carbonate; triethylamine; cesium fluoride; HATU; sodium hydroxide;
palladium diacetate; DavePhos;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; chlorobenzene;
3.1: Suzuki Coupling;
