2-PHENOXYPHENYLACETIC ACID

Base Information

• Chemical Name: 2-PHENOXYPHENYLACETIC ACID
• CAS No.: 25563-02-4
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• Hs Code.: 2918990090
• Mol file: 25563-02-4.mol

Synonyms:2-PHENOXYPHENYLACETIC ACID;RARECHEM AL BO 0332

Chemical Property of 2-PHENOXYPHENYLACETIC ACID

Chemical Property:

• Vapor Pressure: 3.9E-06mmHg at 25°C
• Melting Point: 89-91 °C
• Refractive Index: 1.596
• Boiling Point: 370.2 °C at 760 mmHg
• PKA: 4.09±0.10(Predicted)
• Flash Point: 140.5 °C
• PSA: 46.53000
• Density: 1.217 g/cm³
• LogP: 3.10600

Purity/Quality:

97% ^*data from raw suppliers

2-PhenoxyphenylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENOXYPHENYLACETIC ACID

There total 24 articles about 2-PHENOXYPHENYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-phenoxybenzylmagnesium chloride + 2-phenoxybenzyl chloride (5888-53-9) → 2-(2-phenoxyphenyl)acetic acid (25563-02-4)

Guidance literature:

With hydrogenchloride; magnesium; In tetrahydrofuran;

Reference yield:

methyl 2-(2-phenoxyphenyl)acetate (103474-02-8) → 2-(2-phenoxyphenyl)acetic acid (25563-02-4)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jm00364a004

Reference yield:

(2-phenoxyphenyl)methanol (13807-84-6) → 2-(2-phenoxyphenyl)acetic acid (25563-02-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / pyridine; thionyl chloride / benzene / 24 h / Heating

2: 90 percent / dimethylsulfoxide / 24 h / 20 °C

3: 85 percent / potassium hydroxide / ethanol; H₂O / 4 h / Heating

With pyridine; potassium hydroxide; thionyl chloride; In ethanol; water; dimethyl sulfoxide; benzene;

DOI:10.1021/ol0360703

upstream raw materials:

1-morpholino-2-(o-phenoxyphenyl)-1-ethanethione

acetic acid

(2-phenoxy-phenyl)-pyruvic acid

morpholine

Downstream raw materials:

4,6-bis(4-methylpent-3-en-1-yl)-6-methylcyclohexa-1,3-diene-1-carbaldehyde

1-<<β-ethyl>thio>dibenzoxepin

10-[β-(2-phenylethylamino)ethylthio]dibenz[b,f]oxepin

[2-(10,11-Dihydro-dibenzo[b,f]oxepin-10-ylsulfanyl)-ethyl]-phenethyl-amine