METHYL 5,5,5-TRIFLUORO-3-OXOPENTANOATE

Base Information

• Chemical Name: METHYL 5,5,5-TRIFLUORO-3-OXOPENTANOATE
• CAS No.: 915213-24-0
• Molecular Formula: C₆H₇F₃O₃
• Molecular Weight: 184.115
• Mol file: 915213-24-0.mol

Synonyms:5,5,5-trifluoro-3-oxo-pentanoic acid methyl ester

Chemical Property of METHYL 5,5,5-TRIFLUORO-3-OXOPENTANOATE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Methyl5,5,5-trifluoro-3-oxopentanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of METHYL 5,5,5-TRIFLUORO-3-OXOPENTANOATE

There total 4 articles about METHYL 5,5,5-TRIFLUORO-3-OXOPENTANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

methanol (67-56-1) + 3,3,3-trifluoropropanoyl chloride (41463-83-6) → 5,5,5-trifluoro-3-oxo-pentanoic acid methyl ester (915213-24-0)

Guidance literature:

cycl-isopropylidene malonate; 3,3,3-trifluoropropanoyl chloride; With pyridine; In dichloromethane; at 0 - 20 ℃; for 3h;

methanol; In dichloromethane; at 80 ℃; for 5h;

Reference yield:

methanol (67-56-1) + cycl-isopropylidene malonate (2033-24-1) + 3,3,3-trifluoropropanoyl chloride (41463-83-6) → 5,5,5-trifluoro-3-oxo-pentanoic acid methyl ester (915213-24-0)

Guidance literature:

cycl-isopropylidene malonate; 3,3,3-trifluoropropanoyl chloride; With pyridine; dmap; In methanol; dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

methanol; for 5h; Reflux;

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + 3,3,3-trifluoropropanoyl chloride (41463-83-6) → 5,5,5-trifluoro-3-oxo-pentanoic acid methyl ester (915213-24-0)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

upstream raw materials:

methanol

3,3,3-trifluoropropanoyl chloride

cycl-isopropylidene malonate

Downstream raw materials:

6-chloro-4-phenyl-2-(2,2,2-trifluoro-ethyl)-quinoline-3-carboxylic acid methyl ester

(2-amino-6-oxo-1,6-dihydro-pyrimidin-4-yl)-acetic acid methyl ester