(S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid

Base Information

Chemical Name:(S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid
CAS No.:685508-91-2
Molecular Formula:C₂₁H₂₂N₂O₆S
Molecular Weight:430.481
Hs Code.:

Synonyms:(S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid

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Chemical Property of (S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid

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Technology Process of (S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid

There total 7 articles about (S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 685508-80-9
(S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid methyl ester

: 685508-91-2
(S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 5h;
DOI:10.1016/j.bmcl.2003.12.076

Reference yield:

: 4070-48-8
L-Valine methyl ester

: 685508-91-2
(S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / aq. NaHCO₃ / 3 h / 20 °C

2: 86 percent / thionyl chloride / CH₂Cl₂ / 2 h / Heating

3: 90 percent / aq. NaHCO₃ / toluene / 1 h / 20 °C

4: 25 percent / phosphorus oxychloride / 2 h / Heating

5: 100 percent / NaOH / methanol / 5 h / 20 °C

With sodium hydroxide; thionyl chloride; sodium hydrogencarbonate; trichlorophosphate; In methanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2003.12.076

Reference yield:

: 129972-93-6
C₁₁H₁₁NO₄

: 685508-91-2
(S)-2-{4-[5-(4-Methoxy-phenyl)-oxazol-2-yl]-benzenesulfonylamino}-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / HCl / methanol / 48 h / 20 °C

2: 90 percent / aq. NaHCO₃ / toluene / 1 h / 20 °C

3: 25 percent / phosphorus oxychloride / 2 h / Heating

4: 100 percent / NaOH / methanol / 5 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate; trichlorophosphate; In methanol; toluene;
DOI:10.1016/j.bmcl.2003.12.076