3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole

Base Information

Chemical Name:3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole
CAS No.:675109-03-2
Molecular Formula:C₂₂H₁₅N₅OS
Molecular Weight:397.46
Hs Code.:

Synonyms:3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole

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Chemical Property of 3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole

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Technology Process of 3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole

There total 4 articles about 3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3034-53-5,215777-74-5
2-bromo-1,3-thiazole

: 675108-96-0
8-bromo-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole

: 73183-34-3
bis(pinacol)diborane

: 675109-03-2
3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole

Guidance literature:: 8-bromo-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole; bis(pinacol)diborane; With nitrogen; potassium acetate; for 0.5h;

bis-triphenylphosphine-palladium(II) chloride; at 80 ℃; for 4h;

2-bromo-1,3-thiazole; With cesium carbonate; bis-triphenylphosphine-palladium(II) chloride; at 80 ℃; for 72h;

Reference yield:

: 87967-95-1
5-methyl-3-phenylisoxazole-4-carboxaldehyde

: 675109-03-2
3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine; trifluoroacetic acid / dichloromethane / 0.5 h

2.1: nitrogen; potassium acetate / 0.5 h

2.2: 4 h / 80 °C

2.3: 72 h / 80 °C

With nitrogen; bromine; potassium acetate; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 675109-29-2
(6-bromo-3H-isoindol-1-yl)hydrazine

: 675109-03-2
3-(5-methyl-3-phenylisoxazol-4-yl)-8-thiazol-2-yl-5H-[1,2,4]triazolo[3,4-a]isoindole

Guidance literature:: Multi-step reaction with 2 steps

1.1: bromine; trifluoroacetic acid / dichloromethane / 0.5 h

2.1: nitrogen; potassium acetate / 0.5 h

2.2: 4 h / 80 °C

2.3: 72 h / 80 °C

With nitrogen; bromine; potassium acetate; trifluoroacetic acid; In dichloromethane;