N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine

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Chemical Name:N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine
CAS No.:1312549-96-4
Molecular Formula:C₁₉H₂₁ClN₄O
Molecular Weight:356.855
Hs Code.:

Synonyms:N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine

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Chemical Property of N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine

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Technology Process of N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine

There total 2 articles about N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 931-53-3
Cyclohexyl isocyanide

: C₁₂H₁₀ClN₃O

: 1312549-96-4
N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine

Guidance literature:: C₁₂H₁₀ClN₃O; With chloro-trimethyl-silane; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

Cyclohexyl isocyanide; In dichloromethane; acetonitrile; Reflux; Inert atmosphere;
DOI:10.1039/c1ob05336a

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1312549-96-4
N-[8-chloro-2-(4-methoxyphenyl)imidazo[1,2-a]pyrazin-3-yl]-N-cyclohexylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile / 2 h / Inert atmosphere; Reflux

2.1: chloro-trimethyl-silane / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

2.2: Reflux; Inert atmosphere

With chloro-trimethyl-silane; In dichloromethane; acetonitrile; 2.1: Groebke-Blackburn reaction / 2.2: Groebke-Blackburn reaction;
DOI:10.1039/c1ob05336a