2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine

Base Information

• Chemical Name: 2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine
• CAS No.: 1403666-74-9
• Molecular Formula: C₂₅H₂₆BrNO₂
• Molecular Weight: 452.391
• Mol file: 1403666-74-9.mol

Synonyms:2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine

Chemical Property of 2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine

There total 1 articles about 2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-bromobutyraldehyde (38694-47-2) + α,α-diphenyl-5-(dimethylamino)salicyl alcohol (1044218-12-3) → 2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine (1403666-74-9)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; In toluene; at 80 ℃; for 72h; Inert atmosphere;

DOI:10.1039/c2jm35173k

Reference yield: 96.0%

2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine (1403666-74-9) → 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanenitrile (1403666-75-0)

Guidance literature:

With tetraethylammoniumcyanide; In acetonitrile; for 5.5h; Reflux; Inert atmosphere;

DOI:10.1039/c2jm35173k

Reference yield:

2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine (1403666-74-9) → 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid (1403666-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetraethylammoniumcyanide / acetonitrile / 5.5 h / Reflux; Inert atmosphere

2: potassium hydroxide / 2-methoxy-ethanol / 18 h / Reflux; Inert atmosphere

With tetraethylammoniumcyanide; potassium hydroxide; In 2-methoxy-ethanol; acetonitrile;

DOI:10.1039/c2jm35173k

upstream raw materials:

4-bromobutyraldehyde

α,α-diphenyl-5-(dimethylamino)salicyl alcohol

Downstream raw materials:

4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanenitrile

4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid

2,5-dioxopyrrolidin-1-yl 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl) butanoate

N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)-4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanamide