4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid

Base Information

• Chemical Name: 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid
• CAS No.: 1403666-76-1
• Molecular Formula: C₂₆H₂₇NO₄
• Molecular Weight: 417.505

Synonyms:4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid

Chemical Property of 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid

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Technology Process of 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid

There total 2 articles about 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanenitrile (1403666-75-0) → 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid (1403666-76-1)

Guidance literature:

With potassium hydroxide; In 2-methoxy-ethanol; for 18h; Reflux; Inert atmosphere;

DOI:10.1039/c2jm35173k

Reference yield:

2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine (1403666-74-9) → 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid (1403666-76-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetraethylammoniumcyanide / acetonitrile / 5.5 h / Reflux; Inert atmosphere

2: potassium hydroxide / 2-methoxy-ethanol / 18 h / Reflux; Inert atmosphere

With tetraethylammoniumcyanide; potassium hydroxide; In 2-methoxy-ethanol; acetonitrile;

DOI:10.1039/c2jm35173k

Reference yield: 95.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanoic acid (1403666-76-1) → 2,5-dioxopyrrolidin-1-yl 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl) butanoate (1403666-77-2)

Guidance literature:

With diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1039/c2jm35173k

upstream raw materials:

2-(3-bromopropyl)-N,N-dimethyl-4,4-diphenyl-4H-benzo[d][1,3]dioxin-6-amine

4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl)butanenitrile

Downstream raw materials:

2,5-dioxopyrrolidin-1-yl 4-(6-(dimethylamino)-4,4-diphenyl-4H-benzo[d][1,3]dioxin-2-yl) butanoate

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