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38694-47-2

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38694-47-2 Usage

General Description

4-Bromobutyraldehyde is a chemical compound with the molecular formula C4H7BrO. It is a colorless to pale yellow liquid with a pungent, sweet odor. 4-Bromobutyraldehyde is used as a building block in the production of various pharmaceuticals, agrochemicals, and fine chemicals. It is also used as an intermediate in the synthesis of other organic compounds, such as 4-bromobutyric acid and 4-bromobutyric acid ethyl ester. 4-Bromobutyraldehyde is primarily utilized in the research and development of new chemical products and is also used in the manufacturing of flavors and fragrances. However, 4-Bromobutyraldehyde should be handled with care as it can cause irritation to the skin, eyes, and respiratory system if not used properly.

Check Digit Verification of cas no

The CAS Registry Mumber 38694-47-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,6,9 and 4 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 38694-47:
(7*3)+(6*8)+(5*6)+(4*9)+(3*4)+(2*4)+(1*7)=162
162 % 10 = 2
So 38694-47-2 is a valid CAS Registry Number.

38694-47-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-bromobutanal

1.2 Other means of identification

Product number -
Other names 4-bromo-1-butanal

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:38694-47-2 SDS

38694-47-2Relevant articles and documents

Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

Wang, Xiaodong,Liu, Jing,Zhang, Weihe,Stashko, Michael A.,Nichols, James,Miley, Michael J.,Norris-Drouin, Jacqueline,Chen, Zhilong,Machius, Mischa,DeRyckere, Deborah,Wood, Edgar,Graham, Douglas K.,Earp, H. Shelton,Kireev, Dmitri,Frye, Stephen V.

, p. 1044 - 1049 (2016)

Mer tyrosine kinase (MerTK) is aberrantly elevated in various tumor cells and has a normal anti-inflammatory role in the innate immune system. Inhibition of MerTK may provide dual effects against these MerTK-expressing tumors through reducing cancer cell survival and redirecting the innate immune response. Recently, we have designed novel and potent macrocyclic pyrrolopyrimidines as MerTK inhibitors using a structure-based approach. The most active macrocycles had an EC50 below 40 nM in a cell-based MerTK phosphor-protein ELISA assay. The X-ray structure of macrocyclic analogue 3 complexed with MerTK was also resolved and demonstrated macrocycles binding in the ATP binding pocket of the MerTK protein as anticipated. In addition, the lead compound 16 (UNC3133) had a 1.6 h half-life and 16% oral bioavailability in a mouse PK study.

A synthesis of (±)-stemoamide using the intramolecular propargylic Barbier reaction

Bates, Roderick W.,Sridhar

, p. 1979 - 1981 (2009)

A diastereoselective synthesis of the alkaloid stemoamide has been achieved using the intramolecular propargylic Barbier reaction to construct the seven-membered ring. Georg Thieme Verlag Stuttgart.

Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-Nε-trimethyllysine

Reddy, Y. Vijayendar,Al Temimi, Abbas H. K.,White, Paul B.,Mecinovi?, Jasmin

, p. 400 - 403 (2017)

Trimethyllysine hydroxylase (TMLH) is an Fe(II) and 2-oxoglutarate (2OG) dependent oxygenase involved in the biomedically important carnitine biosynthesis pathway. A combination of synthetic and NMR studies provides direct evidence that human TMLH catalyzes the stereoselective conversion of (2S)-Nε-trimethyllysine to (2S,3S)-3-hydroxy-Nε-trimethyllysine.

2-(1-bromocyclobutyl) pyridine and synthesis method thereof

-

Paragraph 0008; 0029; 0040-0041; 0048; 0059-0060; 0067, (2020/11/23)

The invention belongs to the technical field of organic synthesis, and relates to 2- (1-bromocyclobutyl) pyridine and a synthesis method thereof. The 2 -(-1bromocyclobutyl) pyridine can be used as a medical intermediate, and the synthetic method of the compound comprises the following steps: by taking tetrahydropyrane- 2-ketone as a raw material, carrying out nine steps of reactions including substitution, ring closing, hydrolysis, substitution, substitution, reduction, grignard, substitution and substitution to prepare the 2- (-1bromocyclobutyl) pyridine, so that the synthetic route is simple, the cost is low, and the efficiency is high.

Palladium-Catalyzed Aerobic Anti-Markovnikov Oxidation of Aliphatic Alkenes to Terminal Acetals

Komori, Saki,Yamaguchi, Yoshiko,Kataoka, Yasutaka,Ura, Yasuyuki

, p. 3093 - 3099 (2019/03/29)

Terminal acetals were selectively synthesized from various unbiased aliphatic terminal alkenes and 1,2-, 1,3-, or 1,4-diols using a PdCl2(MeCN)2/CuCl catalyst system in the presence of p-toluquinone under 1 atm of O2 and mild reaction conditions. The slow addition of terminal alkenes suppressed the isomerization to internal alkenes successfully. Electron-deficient cyclic alkenes, such as p-toluquinone, were key additives to enhance the catalytic activity and the anti-Markovnikov selectivity. The halogen groups in the alkenes were found to operate as directing groups, suppressing isomerization and increasing the selectivity efficiently.

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