2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

Base Information

• Chemical Name: 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide
• CAS No.: 1469996-72-2
• Molecular Formula: C₂₉H₃₀BrClN₂O₃
• Molecular Weight: 569.926
• Mol file: 1469996-72-2.mol

Synonyms:2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

Chemical Property of 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide

There total 4 articles about 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid (1469996-65-3) + 4-bromo-aniline (106-40-1) → 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide (1469996-72-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 5 - 20 ℃; for 16.5h;

DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

methyl 3-cyclohexyl-L-alaninate hydrochloride (17193-39-4,144644-00-8) → 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide (1469996-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

2: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.ejmech.2013.08.009

Reference yield:

methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3-cyclohexyl]propanoate (1469996-58-4) → 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide (1469996-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / 1,4-dioxane; water / 0.75 h / 50 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16.5 h / 5 - 20 °C

With lithium hydroxide monohydrate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.ejmech.2013.08.009

upstream raw materials:

(2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid

4-bromo-aniline

methyl 3-cyclohexyl-L-alaninate hydrochloride

methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3-cyclohexyl]propanoate

Downstream raw materials:

C₂₂H₂₄BrClN₂O₃