Technology Process of 2-bromo-N-aniline
There total 2 articles about 2-bromo-N-aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
ethyl acetate; benzene;
for 1h;
Ambient temperature;
DOI:10.1021/jo00133a042
- Guidance literature:
-
Multi-step reaction with 2 steps
1: phosphorus pentachloride / diethyl ether / 3 h
2: 82 percent / benzene; ethyl acetate / 1 h / Ambient temperature
With
phosphorus pentachloride;
In
diethyl ether; ethyl acetate; benzene;
DOI:10.1021/jo00133a042
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) sodium hydride / 1.) THF, 0 deg C, 1.5 h, 2a.) 0 deg C, 30 min, 2b.) room temp., 3 h
2: 93 percent / aq. potassium carbonate / methanol / 3 h / Ambient temperature
3: 41 percent / triphenyl phosphine, tri-n-butylamine / palladium acetate / hexamethylphosphoric acid triamide / 48 h / 120 °C / 3800 Torr
4: 84.6 percent / 10percent aq. hydrochloric acid / methanol / 3 h / 50 °C
5: 10 percent / sodium acetate / 3 h / 150 °C
6: 24 percent / MCPBA / CH2Cl2 / 648 h / Ambient temperature
With
hydrogenchloride; tributyl-amine; sodium acetate; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
palladium diacetate;
In
methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;
DOI:10.1021/jo00133a042
