5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde

Base Information

Chemical Name:5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde
CAS No.:94193-48-3
Molecular Formula:C₂₀H₂₀N₂O₅
Molecular Weight:368.389
Hs Code.:

Synonyms:5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde

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Chemical Property of 5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde

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Technology Process of 5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde

There total 2 articles about 5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94193-36-9
4-(3-formyl-4-nitrophenyl)oxybutanoic acid

: 94193-48-3
5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl chloride / benzene; dimethylformamide / 0.5 h

2: Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

With oxalyl dichloride; sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00385a012

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 94193-37-0
4-(3-Formyl-4-nitro-phenoxy)-butyryl chloride

: 94193-48-3
5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde

Guidance literature:: With sodium carbonate; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm00385a012

Reference yield:

: 94193-48-3
5-[4-(3,4-Dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-2-nitro-benzaldehyde

: {2-Amino-5-[4-(3,4-dihydro-1H-isoquinolin-2-yl)-4-oxo-butoxy]-benzylamino}-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) AcONa / ethanol / 0.5 h

2: NaBH₃CN / ethanol / 3 h

3: H₂ / 10percent Pd/C / ethanol

With hydrogen; sodium acetate; sodium cyanoborohydride; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00385a012