N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide

Base Information

Chemical Name:N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide
CAS No.:1245710-99-9
Molecular Formula:C₁₈H₁₂ClFN₄O₂
Molecular Weight:370.77
Hs Code.:

Synonyms:N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide

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Chemical Property of N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide

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Technology Process of N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide

There total 1 articles about N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 848655-77-6
N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)acetamide

: 1245710-99-9
N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide

Guidance literature:: With boron tribromide; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2010.08.004

Reference yield: 83.0%

: 461-31-4
2-fluoroethyl methanesulfonate

: 1245710-99-9
N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide

: 1313378-65-2
N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-(2-fluoro-ethoxy)-quinolin-6-yl]-acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

Reference yield:

: 1245710-99-9
N-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-hydroxyquinolin-6-yl]-acetamide

: 1263388-96-0
{(E)-3-[4-(3-chloro-4-fluorophenylamino)-3-cyano-7-(2-fluoroethoxy)-quinolin-6-ylcarbamoyl]-allyl}-methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 70 °C

2: hydrogenchloride / water / 2.5 h / Reflux

3: trimethylaluminum / toluene / 14 h / 20 °C

With hydrogenchloride; trimethylaluminum; potassium carbonate; In water; N,N-dimethyl-formamide; toluene;