5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

Base Information

Chemical Name:5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde
CAS No.:1402149-84-1
Molecular Formula:C₃₉H₃₅ClN₄O₅S
Molecular Weight:707.25
Hs Code.:

5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

Synonyms:5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

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Chemical Property of 5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

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Technology Process of 5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

There total 8 articles about 5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1402149-83-0
4-{[(3R)-7-(5-formylfuran-2-yl)-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl]methyl}phenyl trifluoromethanesulfonate

: 1679-18-1
4-Chlorophenylboronic acid

: 1402149-84-1
5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm300624s

Reference yield:

: 1311269-20-1
5-[(3R)-3-[(4-hydroxyphenyl)methyl]-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

: 1402149-84-1
5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In 1,2-dimethoxyethane; dichloromethane; water; 2: |Suzuki Coupling;
DOI:10.1021/jm300624s

Reference yield:

: 4692-98-2
5-bromoisatoic anhydride

: 1402149-84-1
5-[(3R)-3-{[4-(4-chlorophenyl)phenyl]methyl}-4-[(4-methoxybenzene)sulfonyl]-1-[(1-methyl-1Himidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl]furan-2-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine; dmap / Reflux; Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 18 h / Reflux; Inert atmosphere

3.1: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; trifluoroacetic anhydride / toluene / 2 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 80 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 1 h / 80 °C / Inert atmosphere

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; potassium carbonate; triethylamine; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; toluene; 5.1: |Suzuki Coupling / 7.1: |Suzuki Coupling;
DOI:10.1021/jm300624s