(2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol

Base Information

Chemical Name:(2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol
CAS No.:500220-33-7
Molecular Formula:C₂₃H₄₂O₅Si
Molecular Weight:426.669
Hs Code.:

Synonyms:(2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol

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Chemical Property of (2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol

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Technology Process of (2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol

There total 12 articles about (2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 900171-35-9
(3R,4S)-4-[(2S,3R)-2-(tert-butyldimethylsilanyloxy)-4-(4-methoxybenzyloxy)-1-methylbutyl]-3-methyloxetan-2-one

: 500220-33-7
(2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol

Guidance literature:: With di(tert-butyl)aluminium hydride; In tetrahydrofuran; hexane; at -50 ℃; for 0.166667h;
DOI:10.1021/ja061938g

Reference yield:

: 866530-02-1
(2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

: 500220-33-7
(2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole; DMAP / dimethylformamide / 20 h / 20 °C

2: 96 percent / tBu₂AlH / tetrahydrofuran; hexane / 0.5 h / -50 °C

3: 91 percent / LiI; O-trimethylsilylquinine; N,N-diisopropylethylamine / CH₂Cl₂; diethyl ether / -78 °C

4: tBu₂AlH / tetrahydrofuran; hexane / 0.17 h / -50 °C

With 1H-imidazole; dmap; (1S,2R,4S,5R)-2-[(S)-(6-methoxyquinolin-4-yl)((trimethylsilyl)oxy)methyl]-5-vinylquinuclidine; di(tert-butyl)aluminium hydride; N-ethyl-N,N-diisopropylamine; lithium iodide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja061938g

Reference yield:

: 500220-30-4
(2S,3R)-3-(tert-butyldimethylsilanyloxy)-5-(4-methoxybenzyloxy)-2-methylpentanal

: 500220-33-7
(2S,3R,4S,5R)-5-(tert-butyldimethylsilanyloxy)-7-(4-methoxybenzyloxy)-2,4-dimethylheptane-1,3-diol

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / LiI; O-trimethylsilylquinine; N,N-diisopropylethylamine / CH₂Cl₂; diethyl ether / -78 °C

2: tBu₂AlH / tetrahydrofuran; hexane / 0.17 h / -50 °C

With (1S,2R,4S,5R)-2-[(S)-(6-methoxyquinolin-4-yl)((trimethylsilyl)oxy)methyl]-5-vinylquinuclidine; di(tert-butyl)aluminium hydride; N-ethyl-N,N-diisopropylamine; lithium iodide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja061938g