(2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

Base Information

Chemical Name:(2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide
CAS No.:866530-02-1
Molecular Formula:C₁₆H₂₅NO₅
Molecular Weight:311.378
Hs Code.:

Synonyms:(2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

Chemical Property:

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Technology Process of (2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

There total 5 articles about (2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 900171-30-4
(3S,4R)-4-[2-(4-methoxybenzyloxy)ethyl]-3-methyloxetan-2-one

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 866530-02-1
(2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

Guidance literature:: With dimethylaluminum chloride; In hexane; dichloromethane; at -25 ℃; for 2h;
DOI:10.1021/ja061938g

Reference yield:

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: (S)-4-Benzyl-3-[3-hydroxy-5-(4-methoxy-benzyloxy)-2-methyl-pentanoyl]-oxazolidin-2-one

: 866530-02-1
(2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

Guidance literature:: With trimethylaluminum; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/ol027211o

Reference yield:

: 5689-71-4
2-(4-methoxy-phenyl)-[1,3]dioxane

: 866530-02-1
(2S,3R)-N-methoxy-N-methyl-3-hydroxy-5-(4-methoxybenzyloxy)-2-methylpentamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminum hydride / CH₂Cl₂ / 0 °C

2.1: pyridinium chlorochromate / CH₂Cl₂

3.1: n-Bu₂BOTf; triethylamine / CH₂Cl₂ / -5 °C

3.2: 87 percent / CH₂Cl₂ / -78 °C

4.1: Me₃Al / tetrahydrofuran / 0 °C

With di-n-butylboryl trifluoromethanesulfonate; trimethylaluminum; diisobutylaluminium hydride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; 3.2: Evans asymmetric aldol condensation;
DOI:10.1021/ol027211o