tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate

Base Information

Chemical Name:tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate
CAS No.:1309752-66-6
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate

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Chemical Property of tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate

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Technology Process of tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate

There total 8 articles about tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1309752-65-5
tert-butyl {2-[(5-amino-2,3-dihydro-1-benzofuran-4-yl)amino]ethyl}carbamate

: 1663-61-2
triethoxymethylbenzene

: 1309752-66-6
tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; at 60 ℃; for 4h;
DOI:10.1021/jm200385u

Reference yield:

: 680217-71-4
(2,6-difluorophenyl)acetic acid ethyl ester

: 1309752-66-6
tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

3: nitric acid / 0.5 h / 0 °C

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

5: lithium hydroxide monohydrate; potassium carbonate / 1,4-dioxane; water / 16 h / 60 °C

6: palladium 10% on activated carbon; water; hydrogen / methanol / 3 h / 20 °C

7: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 60 °C

With lithium aluminium tetrahydride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; nitric acid; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200385u

Reference yield:

: 1309752-64-4
tert-butyl {2-[(5-nitro-2,3-dihydro-1-benzofuran-4-yl)amino]ethyl}carbamate

: 1309752-66-6
tert-butyl [2-(2-phenyl-7,8-dihydro-1H-furo[3,2-e]benzimidazol-1-yl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; water; hydrogen / methanol / 3 h / 20 °C

2: toluene-4-sulfonic acid / tetrahydrofuran / 4 h / 60 °C

With palladium 10% on activated carbon; water; hydrogen; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;
DOI:10.1021/jm200385u