2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate

Base Information

Chemical Name:2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate
CAS No.:1309752-63-3
Molecular Formula:C₁₇H₂₄FN₃O₆
Molecular Weight:385.392
Hs Code.:

Synonyms:2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate

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Chemical Property of 2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate

Chemical Property:

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Technology Process of 2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate

There total 4 articles about 2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 57260-73-8
N-BOC-1,2-diaminoethane

: 1309752-62-2
2-(2,6-difluoro-3-nitrophenyl)ethyl acetate

: 1309752-63-3
2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1021/jm200385u

Reference yield:

: 680217-71-4
(2,6-difluorophenyl)acetic acid ethyl ester

: 1309752-63-3
2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

2: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

3: nitric acid / 0.5 h / 0 °C

4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With lithium aluminium tetrahydride; nitric acid; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm200385u

Reference yield:

: 168766-16-3
2-(2,6-difluorophenyl)ethanol

: 1309752-63-3
2-[2-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-6-fluoro-3-nitrophenyl]ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

2: nitric acid / 0.5 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With nitric acid; potassium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm200385u