(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

Base Information

Chemical Name:(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate
CAS No.:1330630-53-9
Molecular Formula:C₂₈H₃₉NO₂
Molecular Weight:421.623
Hs Code.:

Synonyms:(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

Suppliers and Price of (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

There total 11 articles about (1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1330630-48-2
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-amino-3-phenylpropanoate

: 67-64-1
acetone

: 1330630-53-9
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1330630-53-9
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) bromide / diethyl ether / 0.5 h / -20 °C / Inert atmosphere

1.2: 16.25 h / -20 °C / Inert atmosphere

1.3: 0 °C

2.1: potassium hydroxide / ethanol; water / 3 h / Reflux

3.1: sodium; isopropyl alcohol / toluene / 8 h / Reflux; Inert atmosphere

4.1: dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

4.2: Saturated solution

5.1: 20 wt.% Pd(OH)2/C; hydrogen / ethyl acetate / 18 h / 3800.26 Torr

6.1: sodium cyanoborohydride / methanol / 18 h / 20 °C / Inert atmosphere

With 20 wt.% Pd(OH)2/C; hydrogen; sodium; sodium cyanoborohydride; isopropyl alcohol; potassium hydroxide; copper(I) bromide; In methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.tet.2011.05.102

Reference yield:

: 89-82-7,90449-51-7
pulegone

: 1330630-53-9
(1'R,2'S,5'R)-2'-(2''-phenylpropan-2''-yl)-5'-methylcyclohexyl (R)-3-(isopropylamino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(I) bromide / diethyl ether / 0.5 h / -20 °C / Inert atmosphere

1.2: 16.25 h / -20 °C / Inert atmosphere

1.3: 0 °C

2.1: potassium hydroxide / ethanol; water / 3 h / Reflux

3.1: sodium; isopropyl alcohol / toluene / 8 h / Reflux; Inert atmosphere

4.1: dichloromethane / 18 h / 0 - 20 °C / Inert atmosphere

4.2: Saturated solution

5.1: 20 wt.% Pd(OH)2/C; hydrogen / ethyl acetate / 18 h / 3800.26 Torr

6.1: sodium cyanoborohydride / methanol / 18 h / 20 °C / Inert atmosphere

With 20 wt.% Pd(OH)2/C; hydrogen; sodium; sodium cyanoborohydride; isopropyl alcohol; potassium hydroxide; copper(I) bromide; In methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.tet.2011.05.102