ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate

Base Information

• Chemical Name: ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate
• CAS No.: 1140407-98-2
• Molecular Formula: C₂₁H₁₉ClN₂O₃
• Molecular Weight: 382.846
• Mol file: 1140407-98-2.mol

Synonyms:ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate

Chemical Property of ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate

There total 1 articles about ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

ethyl bromoacetate (105-36-2) + 5-benzyl-3-(4-chlorophenyl)-1,6-dihydro-6-pyridazinone (66122-36-9) → ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate (1140407-98-2)

Guidance literature:

5-benzyl-3-(4-chlorophenyl)-1,6-dihydro-6-pyridazinone; With sodium hydrogencarbonate; potassium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 84h;

DOI:10.1248/cpb.56.1717

Reference yield: 90.2%

ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate (1140407-98-2) → 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid (1140408-07-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Reflux;

DOI:10.1248/cpb.56.1717

upstream raw materials:

ethyl bromoacetate

5-benzyl-3-(4-chlorophenyl)-1,6-dihydro-6-pyridazinone

Downstream raw materials:

2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid