2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid

Base Information

• Chemical Name: 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid
• CAS No.: 1140408-07-6
• Molecular Formula: C₁₉H₁₅ClN₂O₃
• Molecular Weight: 354.793
• Mol file: 1140408-07-6.mol

Synonyms:2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid

Chemical Property of 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid

There total 1 articles about 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.2%

ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate (1140407-98-2) → 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid (1140408-07-6)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Reflux;

DOI:10.1248/cpb.56.1717

Reference yield: 95.0%

2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid (1140408-07-6) + L-phenylalanine tert-butyl ester (16874-17-2) → tert-butyl 2-(2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetamido)-3-phenyl-propanoate (1140408-26-9)

Guidance literature:

2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.05h;

L-phenylalanine tert-butyl ester; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1248/cpb.56.1717

Reference yield: 85.7%

2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid (1140408-07-6) + tert-butyl (S)-3-(4-(tert-butoxy)phenyl)-2-aminopropanoate (61342-80-1) → tert-butyl 2-(2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetamido)-3-(4-tert-butoxyphenyl)propanoate (1140408-24-7)

Guidance literature:

2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.05h;

tert-butyl (S)-3-(4-(tert-butoxy)phenyl)-2-aminopropanoate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1248/cpb.56.1717

upstream raw materials:

ethyl 2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetate

Downstream raw materials:

tert-butyl 2-(2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetamido)-3-phenyl-propanoate

tert-butyl 2-(2-(5-benzyl-3-(4-chlorophenyl)-6-oxopyridazin-1(6H)-yl)acetamido)-3-(4-tert-butoxyphenyl)propanoate