N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

Base Information

Chemical Name:N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide
CAS No.:201355-27-3
Molecular Formula:C₂₃H₃₆N₆O₅S
Molecular Weight:508.642
Hs Code.:

Synonyms:N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

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Chemical Property of N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

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Technology Process of N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

There total 17 articles about N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 201355-26-2
C₂₃H₃₅N₇O₇S

: 201355-27-3
N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; under 2327.2 - 3102.9 Torr;
DOI:10.1021/jm960572n

Reference yield:

: 21568-87-6
2-aminocaprolactam

: 201355-27-3
N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / NaHCO₃ / tetrahydrofuran / 0 - 20 °C

2: 1.) LiHMDS / 1.) THF, RT, 2.) THF, from 0 deg C to RT

3: 100 percent / HCl / ethyl acetate / 0 - 20 °C

4: Et₃N / acetonitrile / 0 - 20 °C

5: 95 percent / aq. LiOH / ethanol / 0 - 20 °C

6: EDC, HOBt, DIPEA / acetonitrile

7: 100 percent / H₂, aq. AcOH / Pd/C / ethanol / 2327.2 - 3102.9 Torr

With hydrogenchloride; lithium hydroxide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/jm960572n

Reference yield:

: 76944-95-1
tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate

: 201355-27-3
N-((S)-1-Carbamimidoyl-2-ethoxy-piperidin-3-yl)-2-((S)-2-oxo-3-phenylmethanesulfonylamino-azepan-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LiHMDS / 1.) THF, RT, 2.) THF, from 0 deg C to RT

2: 100 percent / HCl / ethyl acetate / 0 - 20 °C

3: Et₃N / acetonitrile / 0 - 20 °C

4: 95 percent / aq. LiOH / ethanol / 0 - 20 °C

5: EDC, HOBt, DIPEA / acetonitrile

6: 100 percent / H₂, aq. AcOH / Pd/C / ethanol / 2327.2 - 3102.9 Torr

With hydrogenchloride; lithium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In ethanol; ethyl acetate; acetonitrile;
DOI:10.1021/jm960572n