N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine

Base Information

• Chemical Name: N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine
• CAS No.: 100701-09-5
• Molecular Formula: C₆₂H₅₄N₅O₈P
• Molecular Weight: 1028.11

Synonyms:N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine

Chemical Property of N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine

Chemical Property:

Purity/Quality:

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Technology Process of N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine

There total 4 articles about N²-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

diphenyl [(triphenylphosphoranylidene)methyl]phosphonate (22400-41-5) + 3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde (100683-69-0) → N2-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine (100701-09-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 168h; Ambient temperature;

DOI:10.1021/jm00155a015

Reference yield:

ganciclovir (82410-32-0) → N2-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine (100701-09-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 43 percent / triethylamine, 4-(dimethylamino)pyridine / dimethylformamide / 2 h / 40 °C

2: 9.5 g / dicyclohexylcarbodiimide, methylphosphonic acid / dimethylsulfoxide / 1.) 18 deg C, 5 h, 2.) RT, 16 h

3: 43 percent / triethylamine / tetrahydrofuran / 168 h / Ambient temperature

With dmap; methylphosphonic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1021/jm00155a015

Reference yield:

9-[({1-hydroxy-3-[(4-methoxyphenyl)-diphenylmethoxy]propan-2-yl}oxy)methyl]-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one (88110-86-5) → N2-(p-anisyldiphenylmethyl)-9-<<<4-(p-anisyldiphenylmethoxy)-1(E)-(diphenoxyphosphinyl)but-1-en-3-yl>oxy>-methyl>guanine (100701-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 9.5 g / dicyclohexylcarbodiimide, methylphosphonic acid / dimethylsulfoxide / 1.) 18 deg C, 5 h, 2.) RT, 16 h

2: 43 percent / triethylamine / tetrahydrofuran / 168 h / Ambient temperature

With methylphosphonic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1021/jm00155a015

upstream raw materials:

diphenyl [(triphenylphosphoranylidene)methyl]phosphonate

3-[(4-Methoxy-phenyl)-diphenyl-methoxy]-2-(2-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-6-oxo-1,6-dihydro-purin-9-ylmethoxy)-propionaldehyde

ganciclovir

9-[({1-hydroxy-3-[(4-methoxyphenyl)-diphenylmethoxy]propan-2-yl}oxy)methyl]-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one

Downstream raw materials:

N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1-(diphenoxyphosphinyl)-3-butoxy>-methyl>guanine

9-<<1--4-hydroxy-3-butoxy>-methyl>guanine

N²-(p-anisyldiphenylmethyl)-9-<<4-(p-anisyldiphenylmethoxy)-1--3-butoxy>methyl>guanine

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