(4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone

Base Information

Chemical Name:(4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone
CAS No.:1370414-68-8
Molecular Formula:C₂₄H₂₉NO₂
Molecular Weight:363.5
Hs Code.:

Synonyms:(4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone

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Chemical Property of (4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone

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Technology Process of (4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone

There total 7 articles about (4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1202394-93-1
(1S,2R,3aS,5aS,6S,8S,9aR)-8-methyl-1,2-diphenyldecahydrooxazolo[3,2-a]quinolin-6-ol

: 1370414-68-8
(4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone

Guidance literature:: With platinum(IV) oxide; hydrogen; In methanol; at 25 ℃; for 40h; under 760.051 Torr; Inert atmosphere;
DOI:10.1021/jo300353t

Reference yield:

: 1202394-90-8
2-hydroxy-7-methyl-2,3,4,6,7,8-hexahydro-chromen-5-one

: 1370414-68-8
(4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone

Guidance literature:: Multi-step reaction with 3 steps

1: copper(II) bis(trifluoromethanesulfonate) / Inert atmosphere

2: sodium; isopropyl alcohol / tetrahydrofuran / -20 °C / Inert atmosphere

3: platinum(IV) oxide; hydrogen / methanol / 40 h / 25 °C / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; hydrogen; sodium; copper(II) bis(trifluoromethanesulfonate); isopropyl alcohol; In tetrahydrofuran; methanol;
DOI:10.1021/jo300353t

Reference yield:

: 1202394-92-0
(1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

: 1370414-68-8
(4aS,5S,7S,8aR)-5-hydroxy-7-methyloctahydro-1-[(1R)-1,2-diphenylethyl]-2(1H)-quinolinone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium; isopropyl alcohol / tetrahydrofuran / -20 °C / Inert atmosphere

2: platinum(IV) oxide; hydrogen / methanol / 40 h / 25 °C / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; hydrogen; sodium; isopropyl alcohol; In tetrahydrofuran; methanol;
DOI:10.1021/jo300353t