(1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

Base Information

Chemical Name:(1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one
CAS No.:1202394-92-0
Molecular Formula:C₂₄H₂₅NO₂
Molecular Weight:359.468
Hs Code.:

Synonyms:(1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

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Chemical Property of (1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

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Technology Process of (1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

There total 2 articles about (1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1202394-90-8
2-hydroxy-7-methyl-2,3,4,6,7,8-hexahydro-chromen-5-one

: (1R,2S)-2-amino-1,2-dibenzylethanol

: 8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

: 1202394-92-0
(1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); magnesium sulfate; In dichloromethane; at 0 ℃; for 22h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol902389e

Reference yield: 95.0%

: 1202394-90-8
2-hydroxy-7-methyl-2,3,4,6,7,8-hexahydro-chromen-5-one

: 23190-16-1
(1R,2S)-2-Amino-1,2-diphenylethanol

: 1202394-92-0
(1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

Guidance literature:: With copper(II) bis(trifluoromethanesulfonate); Inert atmosphere;
DOI:10.1021/jo300353t

Reference yield: 67.0%

: 1202394-92-0
(1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one

: 1202394-93-1
(1S,2R,3aS,5aS,6S,8S,9aR)-8-methyl-1,2-diphenyldecahydrooxazolo[3,2-a]quinolin-6-ol

Guidance literature:: (1S,2R,3aS,8S)-8-methyl-1,2-diphenyl-1,2,3a,4,5,7,8,9-octahydro-oxazolo[3,2-a]quinolin-6-one; With sodium; isopropyl alcohol; In tetrahydrofuran; at -78 - -20 ℃; Inert atmosphere;

With water; sodium chloride; In tetrahydrofuran; methanol; at 20 ℃; optical yield given as %de;
DOI:10.1021/ol902389e